1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Base Information

Chemical Name:1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one
CAS No.:1332454-07-5
Molecular Formula:C₂₉H₃₂N₄O₂
Molecular Weight:468.599
Hs Code.:
Mol file:1332454-07-5.mol

Synonyms:1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Suppliers and Price of 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PK-THPP
10mg
$ 475.00

Tocris
PK-THPP ≥99%(HPLC)
50
$ 918.00

Tocris
PK-THPP ≥99%(HPLC)
10
$ 219.00

Cayman Chemical
PK-THPP
10mg
$ 180.00

Cayman Chemical
PK-THPP
5mg
$ 99.00

Cayman Chemical
PK-THPP
1mg
$ 36.00

Cayman Chemical
PK-THPP
25mg
$ 405.00

American Custom Chemicals Corporation
PK-THPP 99.00%
5MG
$ 501.37

Total 5 raw suppliers

Chemical Property of 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Chemical Property:

Storage Temp.:2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

PK-THPP ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

There total 5 articles about 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3509-15-7
1-piperidin-4-yl-butan-1-one

: 1332455-32-9
biphenyl-4-yl-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

: 1332454-07-5
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃; for 3h;

Reference yield:

: 1454-53-1
ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

: 1332454-07-5
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium alcoholate / ethanol / 2 h / Reflux

2: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

3: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

4: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

5: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 80 °C

With formic acid; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332454-07-5
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

3: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 80 °C

With formic acid; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;