3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

Base Information

Chemical Name:3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione
CAS No.:477338-29-7
Molecular Formula:C₂₀H₁₇NO₉
Molecular Weight:415.356
Hs Code.:

Synonyms:3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

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Chemical Property of 3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

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Technology Process of 3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

There total 6 articles about 3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 19193-05-6
3,4-dihydro-4-keto-6,7-dimethoxyisocoumarin

: 20357-25-9
6-nitroveratraldehyde

: 477338-29-7
3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

Guidance literature:: With ammonium acetate; In acetic acid; at 60 ℃; for 6h;
DOI:10.1016/S0040-4039(02)00990-5

Reference yield:

: 17667-32-2
methyl 6-bromo-3,4-dimethoxybenzoate

: 477338-29-7
3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃; Et₃N / Pd(OAc)2 / acetonitrile / 16 h / 100 °C

2: HCl / H₂O; tetrahydrofuran / 1 h / 20 °C

3: 98 percent / H₂SO₄ / H₂O; dioxane / 2 h / Heating

4: 90 percent / Br₂ / acetic acid; toluene / 0.5 h / 60 °C

5: 95 percent / NaOAc / ethanol / 0.5 h / 20 °C

6: 88 percent / NH₄OAc / acetic acid / 6 h / 60 °C

With hydrogenchloride; sulfuric acid; ammonium acetate; bromine; sodium acetate; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetic acid; toluene; acetonitrile; 1: Heck coupling;
DOI:10.1016/S0040-4039(02)00990-5

Reference yield:

: 58657-20-8
4',5'-Dimethoxy-2'-carboxyacetophenon

: 477338-29-7
3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Br₂ / acetic acid; toluene / 0.5 h / 60 °C

2: 95 percent / NaOAc / ethanol / 0.5 h / 20 °C

3: 88 percent / NH₄OAc / acetic acid / 6 h / 60 °C

With ammonium acetate; bromine; sodium acetate; In ethanol; acetic acid; toluene;
DOI:10.1016/S0040-4039(02)00990-5