58657-20-8

Upstream product

• 477338-23-1 methyl methyl 2-(1-butoxyvinyl)-4,5-dimethoxybenzoate 
• 17667-32-2 methyl 6-bromo-3,4-dimethoxybenzoate 
• 477338-24-2 methyl 2-acetyl-4,5-dimethoxybenzoate 

Downstream Products

• 477338-29-7 3-[1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-1,4-dione 
• 477338-27-5 6,7-Dimethoxy-3-[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-isochroman-1,4-dione 
• 477338-26-4 6,7-Dimethoxy-3-[1-phenyl-meth-(Z)-ylidene]-isochroman-1,4-dione 
• 221189-56-6 2-hydroxy-6,7-dimethoxy-3-(2-nitrophenyl)-1,4-naphthoquinone 
• 155602-65-6 2-hydroxy-6,7-dimethoxy-3-phenyl-[1,4]naphthoquinone 
• 477338-25-3 2-(2-Bromo-acetyl)-4,5-dimethoxy-benzoic acid 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of o-acetylbenzoic acids: A new, efficient general route to 2-hydroxy-3-phenyl-1,4-naphthoquinones and indolo[2,3-b]naphthalene-6,11-diones

We describe here a new, efficient general synthesis of o-acetylbenzoic acids by Heck palladium-catalyzed arylation of n-butyl vinyl ether with o-bromobenzoic acid esters and the use of these compounds as starting materials for the synthesis of 3-benzylideneisochroman-1,4-diones, which readily rearrange to 2-hydroxy-3-phenyl-1,4-naphthoquinones. The application of this strategy to the synthesis of indolo[2,3-b]naphthalene-6,11-diones is also described.