C₃₆H₅₁F₃N₈O₇S

Base Information

• Chemical Name: C₃₆H₅₁F₃N₈O₇S
• CAS No.: 943601-17-0
• Molecular Formula: C₃₆H₅₁F₃N₈O₇S
• Molecular Weight: 796.912
• Mol file: 943601-17-0.mol

Synonyms:C₃₆H₅₁F₃N₈O₇S

Chemical Property of C₃₆H₅₁F₃N₈O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₁F₃N₈O₇S

There total 7 articles about C₃₆H₅₁F₃N₈O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 8-{[(2-nitrophenyl)sulfonyl]amino}octylcarbamate (606969-00-0) + 8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol (943601-06-7) → C36H51F3N8O7S (943601-17-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 0.333333h;

DOI:10.1021/ol070376i

Reference yield:

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde (943601-13-6) → C36H51F3N8O7S (943601-17-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 822 mg / sodium borohydride / ethanol / 0.17 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

3: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

4: 100 percent / (+)-camphorsulfonic acid / methanol / 0.5 h / 20 °C

5: 92 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 20 °C

With sodium tetrahydroborate; sodium azide; tetra-(n-butyl)ammonium iodide; (+)-10-camphorsulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Mitsunobu reaction;

DOI:10.1021/ol070376i

Reference yield:

C22H31F3N2O4 (943601-14-7) → C36H51F3N8O7S (943601-17-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

2: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

3: 100 percent / (+)-camphorsulfonic acid / methanol / 0.5 h / 20 °C

4: 92 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 20 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; (+)-10-camphorsulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Mitsunobu reaction;

DOI:10.1021/ol070376i

upstream raw materials:

tert-butyl 8-{[(2-nitrophenyl)sulfonyl]amino}octylcarbamate

8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

C₂₂H₃₁F₃N₂O₄

Downstream raw materials:

C₄₁H₅₇F₃N₁₀O₇S₂

C₃₅H₅₄F₃N₉O₃S