8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

Base Information

Chemical Name:8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol
CAS No.:943601-06-7
Molecular Formula:C₁₇H₂₂F₃N₅O₂
Molecular Weight:385.389
Hs Code.:

Synonyms:8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

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Chemical Property of 8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

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Technology Process of 8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

There total 6 articles about 8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 943601-16-9
3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

: 943601-06-7
8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

Guidance literature:: With (+)-10-camphorsulfonic acid; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/ol070376i

Reference yield:

: 943601-13-6
2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

: 943601-06-7
8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 822 mg / sodium borohydride / ethanol / 0.17 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

3: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

4: 100 percent / (+)-camphorsulfonic acid / methanol / 0.5 h / 20 °C

With sodium tetrahydroborate; sodium azide; tetra-(n-butyl)ammonium iodide; (+)-10-camphorsulfonic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol070376i

Reference yield:

: 943601-14-7
C₂₂H₃₁F₃N₂O₄

: 943601-06-7
8-[2-azidomethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy]octan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

2: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

3: 100 percent / (+)-camphorsulfonic acid / methanol / 0.5 h / 20 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; (+)-10-camphorsulfonic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol070376i