4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine

Base Information

• Chemical Name: 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine
• CAS No.: 1085525-54-7
• Molecular Formula: C₁₆H₁₂F₃N₃O₂S
• Molecular Weight: 367.351
• Mol file: 1085525-54-7.mol

Synonyms:4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine

Chemical Property of 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine

There total 1 articles about 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

C9H6F3NO2 (357651-51-5) + 4-(methylsulfonyl)phenylhydrazine hydrochloride (17852-67-4) → 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine (1085525-54-7) + 4,4,4-trifluoro-3-[(4-(methanesulfonyl)phenyl)-hydrazono]-1-(pyridin-4-yl)butan-1-one (1085525-52-5)

Guidance literature:

In ethanol; water; for 20h; Reflux;

DOI:10.1016/j.bmc.2008.08.059

Reference yield: 90.0%

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine (1085525-54-7) + methyl iodide (74-88-4) → 1-methyl-4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridinium iodide (1085525-55-8)

Guidance literature:

In acetone; at 25 ℃; for 12h;

DOI:10.1016/j.bmc.2008.08.059

Reference yield: 77.0%

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridine (1085525-54-7) → 1-(4-methanesulfonylphenyl)-5-(piperidin-4-yl)-3-trifluoromethyl-1H-pyrazole (1219688-95-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; at 25 ℃; for 20h; under 3102.97 Torr; Autoclave;

DOI:10.1016/j.bmcl.2010.01.014

upstream raw materials:

C₉H₆F₃NO₂

4-(methylsulfonyl)phenylhydrazine hydrochloride

Downstream raw materials:

1-methyl-4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]pyridinium iodide

1-(4-methanesulfonylphenyl)-5-(piperidin-4-yl)-3-trifluoromethyl-1H-pyrazole