benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

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Chemical Name:benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate
CAS No.:1428533-39-4
Molecular Formula:C₂₇H₃₁ClN₄O₄
Molecular Weight:511.021
Hs Code.:

Synonyms:benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

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Chemical Property of benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

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Technology Process of benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

There total 5 articles about benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1118-12-3
1,1-dimethylethylurea

: 1428533-23-6
benzyl 2-(3,5-dichloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

: 1428533-39-4
benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; at 100 ℃; for 0.25h; chemoselective reaction; Microwave irradiation;
DOI:10.1021/jm301887f

Reference yield:

: 2462-31-9
benzyl 2-aminoacetate hydrochloride

: 1428533-39-4
benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 0.02 h / 20 °C

1.2: 1 h / Reflux

2.1: hydrogenchloride / diethyl ether / 0.08 h

2.2: Reflux

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis;
DOI:10.1021/jm301887f

Reference yield:

: 18328-11-5
3-benzyl propionaldehyde

: 1428533-39-4
benzyl 2-(3-(3-(tert-butyl)ureido)-5-chloro-2-oxo-6-(3-phenylpropyl)pyrazin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 0.02 h / 20 °C

1.2: 1 h / Reflux

2.1: hydrogenchloride / diethyl ether / 0.08 h

2.2: Reflux

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis;
DOI:10.1021/jm301887f