sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Base Information

Chemical Name:sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate
CAS No.:1431300-69-4
Molecular Formula:C₂₂H₁₉N₄O₃S*Na
Molecular Weight:442.474
Hs Code.:

Synonyms:sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Suppliers and Price of sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

There total 8 articles about sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1426856-69-0
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

: 1431300-69-4
sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; for 2h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1431300-69-4
sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

2: water; sodium hydroxide / methanol / 3 h / 50 °C

3: sodium hydroxide / tetrahydrofuran; water / 2 h

With water; palladium diacetate; potassium carbonate; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1431300-69-4
sodium 3-((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3.1: water; sodium hydroxide / methanol / 3 h / 50 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 2 h

With di-isopropyl azodicarboxylate; water; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2.1: |Suzuki Coupling;