3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid
CAS No.:1426856-69-0
Molecular Formula:C₂₂H₂₀N₄O₃S
Molecular Weight:420.492
Hs Code.:

Synonyms:3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

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Technology Process of 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

There total 7 articles about 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 1426857-56-8
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1426856-69-0
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 50 ℃; for 3h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1426856-69-0
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

2: water; sodium hydroxide / methanol / 3 h / 50 °C

With water; palladium diacetate; potassium carbonate; sodium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1426856-69-0
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3.1: water; sodium hydroxide / methanol / 3 h / 50 °C

With di-isopropyl azodicarboxylate; water; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2.1: |Suzuki Coupling;