3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

Base Information

Chemical Name:3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester
CAS No.:1426857-56-8
Molecular Formula:C₂₃H₂₂N₄O₃S
Molecular Weight:434.519
Hs Code.:

Synonyms:3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

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Chemical Property of 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

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Technology Process of 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

There total 5 articles about 3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.2%

: 330793-85-6
N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzothiazol-2-ylamine

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1426857-56-8
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

Guidance literature:: With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1426857-56-8
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

With di-isopropyl azodicarboxylate; palladium diacetate; potassium carbonate; triphenylphosphine; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Suzuki Coupling;

Reference yield:

: 6278-86-0
N₂-(4-bromophenyl)-1,3-benzothiazol-2-amine

: 1426857-56-8
3-(5-(4-(benzothiazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 140 °C / Inert atmosphere

2: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

With potassium acetate; palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; 2: |Suzuki Coupling;