C₂₂H₁₅F₃N₂O₃

Base Information

Chemical Name:C₂₂H₁₅F₃N₂O₃
CAS No.:1427406-24-3
Molecular Formula:C₂₂H₁₅F₃N₂O₃
Molecular Weight:412.368
Hs Code.:

C<sub>22</sub>H<sub>15</sub>F<sub>3</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₂H₁₅F₃N₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₁₅F₃N₂O₃

Chemical Property:

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Technology Process of C₂₂H₁₅F₃N₂O₃

There total 12 articles about C₂₂H₁₅F₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1427407-58-6
ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

: 1427406-24-3
C₂₂H₁₅F₃N₂O₃

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 40 ℃;

Reference yield:

: 51760-21-5
dimethyl 5-bromoisophthalate

: 1427406-24-3
C₂₂H₁₅F₃N₂O₃

Guidance literature:: Multi-step reaction with 11 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

2: thionyl chloride / Reflux

3: ammonia / tetrahydrofuran

4: trichlorophosphate / 100 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

7: thionyl chloride / Reflux

8: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C

9: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C

10: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

11: lithium hydroxide monohydrate; water / tetrahydrofuran / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 161796-10-7
3-bromo-5-(methoxycarbonyl)benzoic acid

: 1427406-24-3
C₂₂H₁₅F₃N₂O₃

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / Reflux

2: ammonia / tetrahydrofuran

3: trichlorophosphate / 100 °C

4: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

6: thionyl chloride / Reflux

7: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C

8: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C

9: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

10: lithium hydroxide monohydrate; water / tetrahydrofuran / 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;