ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Base Information

Chemical Name:ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate
CAS No.:1427407-58-6
Molecular Formula:C₂₄H₁₉F₃N₂O₃
Molecular Weight:440.422
Hs Code.:

Synonyms:ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

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Chemical Property of ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

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Technology Process of ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

There total 11 articles about ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1427407-57-5
3-[(2,6-difluoro-3-hydroxy-anilino)methyl]-5-(3-fluorophenyl)benzonitrile

: 105-36-2
ethyl bromoacetate

: 1427407-58-6
ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: 3-[(2,6-difluoro-3-hydroxy-anilino)methyl]-5-(3-fluorophenyl)benzonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide;

Reference yield:

: 51760-21-5
dimethyl 5-bromoisophthalate

: 1427407-58-6
ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: Multi-step reaction with 10 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

2: thionyl chloride / Reflux

3: ammonia / tetrahydrofuran

4: trichlorophosphate / 100 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

7: thionyl chloride / Reflux

8: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C

9: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C

10: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 23351-91-9
5-bromoisophthalic acid

: 1427407-58-6
ethyl 2-[3-[[3-cyano-5-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenoxy]acetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

3.1: thionyl chloride / Reflux

4.1: ammonia / tetrahydrofuran

5.1: trichlorophosphate / 100 °C

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

8.1: thionyl chloride / Reflux

9.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C

10.1: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;