methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

Base Information

Chemical Name:methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride
CAS No.:913652-19-4
Molecular Formula:C₁₅H₁₈ClN₃O₂S*ClH
Molecular Weight:376.307
Hs Code.:

Synonyms:methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

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Chemical Property of methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

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Technology Process of methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

There total 6 articles about methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 913652-18-3
2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carbonitrile

: 913652-19-4
methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

Guidance literature:: methanol; 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carbonitrile; With sodium hydride; at 20 ℃; for 20h;

With hydrogenchloride; In diethyl ether; water;

Reference yield:

: 913651-35-1
2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboxylic acid

: 913652-19-4
methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

2: trichlorophosphate / 0.02 h / Heating / reflux

3: sodium hydride / 20 h / 20 °C

With N-hydroxybenzotriazole ammonium salt; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In dichloromethane;

Reference yield:

: 913651-34-0
ethyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboxylate

: 913652-19-4
methyl 2-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}amino)-1,3-thiazole-4-carboximidoate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / ethanol / 0.5 h / 80 °C

2: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

3: trichlorophosphate / 0.02 h / Heating / reflux

4: sodium hydride / 20 h / 20 °C

With sodium hydroxide; N-hydroxybenzotriazole ammonium salt; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane;