toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester
CAS No.:250684-32-3
Molecular Formula:C₁₉H₂₅NO₅S
Molecular Weight:379.477
Hs Code.:

Synonyms:toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

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Chemical Property of toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

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Technology Process of toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

There total 6 articles about toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98-59-9
p-toluenesulfonyl chloride

: 250684-31-2
2-hydroxy-3-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-propionitrile

: 250684-32-3
toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/S0040-4020(99)00614-6

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 250684-32-3
toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / toluene / 0 - 20 °C

1.2: 95 percent / toluene / 0 - 80 °C

2.1: 88 percent / DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

3.1: 70 percent / CrO₃; pyridine / CH₂Cl₂ / 0.67 h

4.1: 63 percent / diethyl ether / 2 h / -5 °C

5.1: NaHSO₃ / H₂O; CH₂Cl₂ / 15 h / 20 °C

5.2: 97 percent / H₂O; CH₂Cl₂ / 3 h

6.1: 73 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With pyridine; chromium(VI) oxide; sodium hydride; diisobutylaluminium hydride; sodium hydrogensulfite; triethylamine; In diethyl ether; dichloromethane; water; toluene; 1.1: Metallation / 1.2: Condensation / 2.1: Reduction / 3.1: Oxidation / 4.1: Addition / 5.1: Addition / 5.2: Substitution / 6.1: Tosylation;
DOI:10.1016/S0040-4020(99)00614-6

Reference yield:

: 51656-91-8
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

: 250684-32-3
toluene-4-sulfonic acid 1-cyano-2-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

2.1: 70 percent / CrO₃; pyridine / CH₂Cl₂ / 0.67 h

3.1: 63 percent / diethyl ether / 2 h / -5 °C

4.1: NaHSO₃ / H₂O; CH₂Cl₂ / 15 h / 20 °C

4.2: 97 percent / H₂O; CH₂Cl₂ / 3 h

5.1: 73 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With pyridine; chromium(VI) oxide; diisobutylaluminium hydride; sodium hydrogensulfite; triethylamine; In diethyl ether; dichloromethane; water; toluene; 1.1: Reduction / 2.1: Oxidation / 3.1: Addition / 4.1: Addition / 4.2: Substitution / 5.1: Tosylation;
DOI:10.1016/S0040-4020(99)00614-6