1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

Base Information

Chemical Name:1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone
CAS No.:153397-46-7
Molecular Formula:C₁₉H₂₀F₃NO₂Si
Molecular Weight:379.454
Hs Code.:

Synonyms:1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

Suppliers and Price of 1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

Chemical Property:

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Technology Process of 1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

There total 1 articles about 1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 18042-62-1
N-<(Trimethylsilyl)methyl>phthalimide

: 402-43-7
p-trifluoromethylphenyl bromide

: 153397-46-7
1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

Guidance literature:: With n-butyllithium; 1.) hexane, Et₂O, 2.) Et₂O, 0 deg C;
DOI:10.1021/jo00080a024

Reference yield: 68.0%

: 153397-46-7
1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

: 153397-50-3
1-<4-(Trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindoline

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; Heating;
DOI:10.1021/jo00080a024

Reference yield:

: 153397-46-7
1-Hydroxy-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinone

: cis-2-Methyl-1-<4-(trifluoromethyl)phenyl>-2-<(trimethylsilyl)methyl>isoindolinium iodide

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / LiAlH₄ / diethyl ether / Heating

2: acetonitrile / 5 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; acetonitrile;
DOI:10.1021/jo00080a024