6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one

Base Information

• Chemical Name: 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one
• CAS No.: 110841-23-1
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 110841-23-1.mol

Synonyms:6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one

Chemical Property of 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one

There total 10 articles about 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6,7-dimethoxy-4-(4-methoxyphenyl)-2-methylisoquinolinium perchlorate → 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one (110841-23-1)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III); In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1080/00397910500189841

Reference yield: 98.0%

N-(Diphenyl-phosphinoylmethyl)-4,5-dimethoxy-2-(4-methoxy-benzoyl)-N-methyl-benzamide (178211-34-2) → 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one (110841-23-1)

Guidance literature:

With potassium hexamethyldisilylazide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1016/0040-4039(96)00644-2

Reference yield: 90.0%

3-Hydroxy-6,7-dimethoxy-4-(4-methoxy-phenyl)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one (110841-25-3) → 6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-2H-isoquinolin-1-one (110841-23-1)

Guidance literature:

With sulfuric acid; for 0.166667h; Heating;

DOI:10.1039/c39870000191

upstream raw materials:

3-Hydroxy-6,7-dimethoxy-4-(4-methoxy-phenyl)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one

N-(Diphenyl-phosphinoylmethyl)-4,5-dimethoxy-2-(4-methoxy-benzoyl)-N-methyl-benzamide

4,5-dimethoxyphthalic anhydride

4,5-Dimethoxy-2-(4-methoxy-benzoyl)-benzoic acid

Downstream raw materials:

6,7-dimethoxy-4-(4-methoxyphenyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline

4-(4-hydroxyphenyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

cherylline lactam