C₂₈H₃₇N₇O₂

Base Information

• Chemical Name: C₂₈H₃₇N₇O₂
• CAS No.: 1346411-44-6
• Molecular Formula: C₂₈H₃₇N₇O₂
• Molecular Weight: 503.647
• Mol file: 1346411-44-6.mol

Synonyms:C₂₈H₃₇N₇O₂

Chemical Property of C₂₈H₃₇N₇O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₇N₇O₂

There total 15 articles about C₂₈H₃₇N₇O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C36H39N7O4 (1346245-63-3) → C28H37N7O2 (1346411-44-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 3h;

Reference yield:

7‐bromo‐2‐(1‐methyl‐1H‐pyrazol‐4‐yl)quinoxaline (1083325-87-4) → C28H37N7O2 (1346411-44-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

2.2: 5 - 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

3.2: Cooling with ice

4.1: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

5.1: acetonitrile / 18 h / 100 °C / sealed vessel

6.1: potassium carbonate / acetonitrile / 48 h / 80 °C

7.1: hydrazine hydrate / ethanol / 3 h / 80 °C

With tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

7-bromo-2-chloroquinoxaline (89891-65-6) → C28H37N7O2 (1346411-44-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux

2.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

3.2: 5 - 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

4.2: Cooling with ice

5.1: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

6.1: acetonitrile / 18 h / 100 °C / sealed vessel

7.1: potassium carbonate / acetonitrile / 48 h / 80 °C

8.1: hydrazine hydrate / ethanol / 3 h / 80 °C

With tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; potassium carbonate; hydrazine hydrate; triethylamine; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

3.5-dimethoxyaniline

7-bromo-2-chloroquinoxaline

7‐bromo‐2‐(1‐methyl‐1H‐pyrazol‐4‐yl)quinoxaline

N-(3,5-dimethoxyphenyl)-3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine