diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

Base Information

Chemical Name:diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate
CAS No.:1472707-06-4
Molecular Formula:C₂₅H₄₁NO₁₁P₂
Molecular Weight:593.548
Hs Code.:

Synonyms:diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

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Technology Process of diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

There total 3 articles about diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 6829-40-9
aminomalonic acid diethyl ester

: 37465-31-9
1,1-bis(diethylphosphono)ethylene

: 123-11-5
4-methoxy-benzaldehyde

: 1472707-06-4
diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1338498

Reference yield:

: 1660-94-2
Tetraethyl methylenediphosphonate

: 1472707-06-4
diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamine / 2 h / Reflux

1.2: 24 h / Reflux

2.1: toluene / 48 h / Reflux; Dean-Stark

3.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With diethylamine; In tetrahydrofuran; toluene;
DOI:10.1055/s-0033-1338498

Reference yield:

: 103457-10-9
tetraethyl (1-methylenemethoxy)methylene bisphosphonate

: 1472707-06-4
diethyl (+/-)-4,4-bis(diethoxyphosphoryl)-5-(4-methoxyphenyl)pyrrolidine-2,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 48 h / Reflux; Dean-Stark

2: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

In tetrahydrofuran; toluene;
DOI:10.1055/s-0033-1338498