(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

Base Information

Chemical Name:(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol
CAS No.:900184-02-3
Molecular Formula:C₁₂H₁₆F₃N₃O
Molecular Weight:275.274
Hs Code.:

Synonyms:(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

Chemical Property:

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Technology Process of (R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

There total 1 articles about (R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 900184-02-3
(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / K₂CO₃; Cu / dimethylformamide / 130 °C

2.1: 91 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 20 °C

3.1: 76 percent / Br₂ / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 74 percent / Pd(OAc)2; benzyl triethylammonium chloride / dimethylformamide / 18 h / 40 °C

5.1: aq. OsO₄; N-methylmorpholine N-oxide / acetone / 5 h / 20 °C

5.2: 81 percent / Pb(OAc)4 / CH₂Cl₂ / 0.5 h / 0 °C

6.1: 89 percent / NaBH₄ / methanol / 0.5 h / 0 °C

7.1: 92 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With palladium diacetate; sodium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; bromine; copper; potassium carbonate; 4-methylmorpholine N-oxide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm060065y

Reference yield: 41.0%

: 900184-02-3
(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

: 683241-26-1
2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole

: 683244-29-3
(6-{3-methyl-4-[6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazol-2-yl]-piperazin-1-yl}-5-trifluoromethyl-pyridin-3-yl)-methanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 175 ℃; for 4h; microwave irradiation;
DOI:10.1021/jm060065y

Reference yield:

: 900184-02-3
(R)-(6-(3-methylpiperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol

: 683244-36-2
(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / iPr₂NEt / ethanol / 4 h / 175 °C / microwave irradiation

2: 86 percent / MnO₂ / CH₂Cl₂ / 4 h / 20 °C

With manganese(IV) oxide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jm060065y