(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

Base Information

Chemical Name:(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde
CAS No.:683244-36-2
Molecular Formula:C₂₆H₁₈F₉N₅O
Molecular Weight:587.447
Hs Code.:

Synonyms:(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

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Chemical Property of (R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

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Technology Process of (R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

There total 15 articles about (R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 683244-29-3
(6-{3-methyl-4-[6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazol-2-yl]-piperazin-1-yl}-5-trifluoromethyl-pyridin-3-yl)-methanol

: 683244-36-2
(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm060065y

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 683244-36-2
(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: 86 percent / K₂CO₃; Cu / dimethylformamide / 130 °C

2.1: 91 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 20 °C

3.1: 76 percent / Br₂ / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 74 percent / Pd(OAc)2; benzyl triethylammonium chloride / dimethylformamide / 18 h / 40 °C

5.1: aq. OsO₄; N-methylmorpholine N-oxide / acetone / 5 h / 20 °C

5.2: 81 percent / Pb(OAc)4 / CH₂Cl₂ / 0.5 h / 0 °C

6.1: 89 percent / NaBH₄ / methanol / 0.5 h / 0 °C

7.1: 92 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

8.1: 41 percent / iPr₂NEt / ethanol / 4 h / 175 °C / microwave irradiation

9.1: 86 percent / MnO₂ / CH₂Cl₂ / 4 h / 20 °C

With manganese(IV) oxide; palladium diacetate; sodium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; bromine; copper; potassium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm060065y

Reference yield:

: 683240-52-0
4-bromo-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one

: 683244-36-2
(R)-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)nicotinaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / PdCl₂(PPh₃)2; Na₂CO₃*H₂O / 1,2-dimethoxy-ethane; ethanol; H₂O / 0.17 h / 120 °C / microwave irradiation

2: 61 percent / POCl₃ / 16 h / 95 °C

3: 41 percent / iPr₂NEt / ethanol / 4 h / 175 °C / microwave irradiation

4: 86 percent / MnO₂ / CH₂Cl₂ / 4 h / 20 °C

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;
DOI:10.1021/jm060065y