2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester
CAS No.:1630974-84-3
Molecular Formula:C₁₉H₁₇ClN₂O₅
Molecular Weight:388.807
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

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Chemical Property of 2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

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Technology Process of 2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

There total 7 articles about 2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1630974-75-2
2-(4-chlorophenyl)-3-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

: 3282-30-2
pivaloyl chloride

: 1630974-84-3
2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.5012/bkcs.2014.35.5.1337

Reference yield:

: 98475-07-1
2-bromomethyl-3-nitro-benzoic acid methyl ester

: 1630974-84-3
2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 5 h / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 2.5 h / 20 °C / Inert atmosphere; Reflux

3: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In acetonitrile;
DOI:10.5012/bkcs.2014.35.5.1337

Reference yield:

: 59382-59-1
2-methyl-3-nitro-benzoic acid methyl ester

: 1630974-84-3
2,2-dimethylpropionic acid 2-(4-chlorophenyl)-7-nitro-3-oxo-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 26 h / 20 °C / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 5 h / 20 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 2.5 h / 20 °C / Inert atmosphere; Reflux

4: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.5012/bkcs.2014.35.5.1337