tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

Base Information

Chemical Name:tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine
CAS No.:1028285-96-2
Molecular Formula:C₂₅H₄₂N₂OSi
Molecular Weight:414.707
Hs Code.:

Synonyms:tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

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Chemical Property of tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

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Technology Process of tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

There total 4 articles about tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1028285-96-2
tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / Ambient temperature

2: 1.) BH₃*THF, 2.) aq. NaOH, H₂O₂ / 1.) THF, room temperature, 2 h, 2.) 0 deg C, 3 h

3: 62 percent / I₂, imidazole, PPh₃ / benzene / 1.5 h / Ambient temperature

4: 1.) t-BuLi / 1.) Et₂O, THF, hexane, -20 deg C, 2 h, 2.) Et₂O, THF, hexane, -20 deg C, overnight

With 1H-imidazole; dmap; sodium hydroxide; borane-THF; dihydrogen peroxide; iodine; tert.-butyl lithium; triethylamine; triphenylphosphine; In dichloromethane; benzene;
DOI:10.1021/jo961832b

Reference yield:

: 151950-94-6
1-tert-butyldimethylsilyloxy-2-(2-propenyl)benzene

: 1028285-96-2
tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BH₃*THF, 2.) aq. NaOH, H₂O₂ / 1.) THF, room temperature, 2 h, 2.) 0 deg C, 3 h

2: 62 percent / I₂, imidazole, PPh₃ / benzene / 1.5 h / Ambient temperature

3: 1.) t-BuLi / 1.) Et₂O, THF, hexane, -20 deg C, 2 h, 2.) Et₂O, THF, hexane, -20 deg C, overnight

With 1H-imidazole; sodium hydroxide; borane-THF; dihydrogen peroxide; iodine; tert.-butyl lithium; triphenylphosphine; In benzene;
DOI:10.1021/jo961832b

Reference yield:

: 327155-45-3
3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol

: 1028285-96-2
tert-Butyl-[1-(6-{3-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / I₂, imidazole, PPh₃ / benzene / 1.5 h / Ambient temperature

2: 1.) t-BuLi / 1.) Et₂O, THF, hexane, -20 deg C, 2 h, 2.) Et₂O, THF, hexane, -20 deg C, overnight

With 1H-imidazole; iodine; tert.-butyl lithium; triphenylphosphine; In benzene;
DOI:10.1021/jo961832b