N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide
CAS No.:1095003-58-9
Molecular Formula:C₂₇H₃₃N₅O₂
Molecular Weight:459.591
Hs Code.:

Synonyms:N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

There total 8 articles about N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1095006-95-3
N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

: 506-59-2
N,N-dimethylammonium chloride

: 1095003-58-9
N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 17h;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 1095005-68-7
methyl 3-(3-((1R,2R)-3-hydroxy-2-methyl-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095003-58-9
N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 0.52 h / 25 °C

3: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 25 °C

With isopropylmagnesium chloride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 1095003-51-2
N-cyclopropyl-3-[3-{[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

: 1095003-58-9
N-cyclopropyl-3-[3-{[(1R,2S)-3-(dimethylamino)-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 0.52 h / 25 °C

2: N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 25 °C

With sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2020.127412