5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate
• CAS No.: 93183-95-0
• Molecular Formula: C₅₂H₅₁ClN₇O₁₂P
• Molecular Weight: 1032.44

Synonyms:5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

Chemical Property of 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

Chemical Property:

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Technology Process of 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

There total 2 articles about 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-isobutyrylamino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester + 3-Hydroxypropionitrile (109-78-4) → 2-chlorophenyl bis<2-cyanoethyl>phosphate (96404-97-6) + 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93183-95-0)

Guidance literature:

With 1-methyl-1H-imidazole; In 1,4-dioxane;

Reference yield:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate (80817-46-5) + 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1) + 3-Hydroxypropionitrile (109-78-4) → 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93183-95-0)

Guidance literature:

With 1-methyl-1H-imidazole; Yield given. Multistep reaction; 1.) THF, pyridine, 20 deg C, 15 min; 2.) THF, pyridine, 20 deg C, 2 h;

DOI:10.1002/hlca.19840670521

Reference yield: 92.0%

5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93183-95-0) → N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93130-38-2)

Guidance literature:

With dichloro-acetic acid; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1002/hlca.19840670521

upstream raw materials:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine

3-Hydroxypropionitrile

Downstream raw materials:

N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate

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