Technology Process of 1,1-(1,2-Benzenediyldithio)-4-(3,4,5-trimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene
There total 10 articles about 1,1-(1,2-Benzenediyldithio)-4-(3,4,5-trimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
acetonitrile;
at 5 ℃;
for 8h;
DOI:10.1021/jo00304a021
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / SnCl2 / CH2Cl2 / 6 h / Ambient temperature
2: 85 percent / toluene / 5 h / Heating
3: 93 percent / H2 / Pd / C / ethanol / Ambient temperature
4: 92 percent / LiAlH4 / diethyl ether / 0.33 h / 0 °C
5: 80 percent / 1.)oxalyl chloride, DMSO, 2.)triethylamine / 1.)CH2Cl2, -60 deg C, 15 min., 2.)H2O, r.t., 30 min.
6: 88 percent / tetrahydrofuran / -78 - 20 °C
7: 86 percent / p-toluenesulfonic acid / acetonitrile / 8 h / 5 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; tin(ll) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00304a021
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / toluene / 5 h / Heating
2: 93 percent / H2 / Pd / C / ethanol / Ambient temperature
3: 92 percent / LiAlH4 / diethyl ether / 0.33 h / 0 °C
4: 80 percent / 1.)oxalyl chloride, DMSO, 2.)triethylamine / 1.)CH2Cl2, -60 deg C, 15 min., 2.)H2O, r.t., 30 min.
5: 88 percent / tetrahydrofuran / -78 - 20 °C
6: 86 percent / p-toluenesulfonic acid / acetonitrile / 8 h / 5 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; toluene; acetonitrile;
DOI:10.1021/jo00304a021
