4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

Base Information

Chemical Name:4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone
CAS No.:129150-02-3
Molecular Formula:C₂₁H₂₄O₆
Molecular Weight:372.418
Hs Code.:

Synonyms:4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

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Chemical Property of 4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

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Technology Process of 4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

There total 9 articles about 4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 129150-01-2
1,1-(1,2-Benzenediyldithio)-4-(3,4,5-trimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene

: 129150-02-3
4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

Guidance literature:: With boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; water; for 0.5h; Heating;
DOI:10.1021/jo00304a021

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 129150-02-3
4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / SnCl₂ / CH₂Cl₂ / 6 h / Ambient temperature

2: 85 percent / toluene / 5 h / Heating

3: 93 percent / H₂ / Pd / C / ethanol / Ambient temperature

4: 92 percent / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

5: 80 percent / 1.)oxalyl chloride, DMSO, 2.)triethylamine / 1.)CH₂Cl₂, -60 deg C, 15 min., 2.)H₂O, r.t., 30 min.

6: 88 percent / tetrahydrofuran / -78 - 20 °C

7: 86 percent / p-toluenesulfonic acid / acetonitrile / 8 h / 5 °C

8: 69 percent / red mercury(II) oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 0.5 h / Heating

With lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; tin(ll) chloride; mercury(II) oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo00304a021

Reference yield:

: 22699-97-4
(3,4-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanone

: 129150-02-3
4-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-1-tetralone

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / toluene / 5 h / Heating

2: 93 percent / H₂ / Pd / C / ethanol / Ambient temperature

3: 92 percent / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

4: 80 percent / 1.)oxalyl chloride, DMSO, 2.)triethylamine / 1.)CH₂Cl₂, -60 deg C, 15 min., 2.)H₂O, r.t., 30 min.

5: 88 percent / tetrahydrofuran / -78 - 20 °C

6: 86 percent / p-toluenesulfonic acid / acetonitrile / 8 h / 5 °C

7: 69 percent / red mercury(II) oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 0.5 h / Heating

With lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; mercury(II) oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jo00304a021