Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester
CAS No.:451478-52-7
Molecular Formula:C₁₉H₂₄NO₃P
Molecular Weight:345.378
Hs Code.:
DSSTox Substance ID:DTXSID401142615

Synonyms:DTXSID401142615;Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester;451478-52-7

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Chemical Property of Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:345.14938063
Heavy Atom Count:24
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(C)CP(=O)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [(diphenylphosphinyl)methyl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 122365-23-5
N-[(diphenylphosphinoyl)methyl]-N-methylamine

: 451478-52-7
N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine

Guidance literature:: In tetrahydrofuran; for 3h; Heating;
DOI:10.1021/jo0202379

Reference yield:

: 451478-52-7
N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine

: 451478-50-5
2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde

: 451478-55-0
2-(4,5-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Guidance literature:: N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

With ammonium formate; 10percent Pd/C; In methanol; for 0.5h; Further stages.; Heating;
DOI:10.1021/jo0202379

Reference yield:

: 451478-52-7
N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine

: 451478-51-6
2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-3,4-dimethoxyphenyl)benzaldehyde

: 451478-56-1
2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Guidance literature:: N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-3,4-dimethoxyphenyl)benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

With ammonium formate; 10percent Pd/C; In methanol; for 0.5h; Further stages.; Heating;
DOI:10.1021/jo0202379