2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde

Base Information

• Chemical Name: 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde
• CAS No.: 451478-50-5
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.391

Synonyms:2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde

Chemical Property of 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde

There total 3 articles about 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-(2-[1,3]dioxol-2-ylphenyl)-4,5-dimethoxyphenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole (451478-48-1) → 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde (451478-50-5)

Guidance literature:

With iron(III) chloride; In dichloromethane; acetone; at 20 ℃; for 2h;

DOI:10.1021/jo0202379

Reference yield:

4,4-dimethyl-2-(2,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazole (64957-88-6) → 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde (451478-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; 1,2-dibromotetrafluoroethane / tetrahydrofuran / 1 h

1.2: 76 percent / tetrahydrofuran

2.1: 92 percent / iron(III) chloride hexahydrate / acetone; CH₂Cl₂ / 2 h / 20 °C

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; iron(III) chloride; magnesium; In tetrahydrofuran; dichloromethane; acetone; 1.2: Meyers coupling;

DOI:10.1021/jo0202379

Reference yield:

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) → 2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-4,5-dimethoxyphenyl)benzaldehyde (451478-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; 1,2-dibromotetrafluoroethane / tetrahydrofuran / 1 h

1.2: 76 percent / tetrahydrofuran

2.1: 92 percent / iron(III) chloride hexahydrate / acetone; CH₂Cl₂ / 2 h / 20 °C

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; iron(III) chloride; magnesium; In tetrahydrofuran; dichloromethane; acetone; 1.2: Meyers coupling;

DOI:10.1021/jo0202379

upstream raw materials:

2-(2-(2-[1,3]dioxol-2-ylphenyl)-4,5-dimethoxyphenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

4,4-dimethyl-2-(2,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazole

2-(2-bromophenyl)-1,3-dioxolan

Downstream raw materials:

2-(4,5-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

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