2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Base Information

Chemical Name:2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole
CAS No.:451478-56-1
Molecular Formula:C₂₇H₃₆N₂O₅
Molecular Weight:468.593
Hs Code.:

Synonyms:2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

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Chemical Property of 2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

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Technology Process of 2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

There total 5 articles about 2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 451478-52-7
N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine

: 451478-51-6
2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-3,4-dimethoxyphenyl)benzaldehyde

: 451478-56-1
2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Guidance literature:: N-(tert-butoxycarbonyl)-N-[(diphenylphosphinoyl)methyl]-N-methylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

2-(2-(4,4-dimethyl-4,5-dihydro[1,3]oxazol-2-yl)-3,4-dimethoxyphenyl)benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

With ammonium formate; 10percent Pd/C; In methanol; for 0.5h; Further stages.; Heating;
DOI:10.1021/jo0202379

Reference yield:

: 34824-58-3
2-(2-bromophenyl)-1,3-dioxolan

: 451478-56-1
2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; 1,2-dibromotetrafluoroethane / tetrahydrofuran / 1 h

1.2: 81 percent / tetrahydrofuran

2.1: 89 percent / iron(III) chloride hexahydrate / acetone; CH₂Cl₂ / 2 h / 20 °C

3.1: BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

3.2: hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3.3: 1.33 g / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

With n-butyllithium; 1,2-dibromo-1,1,2,2-tetrafluoroethane; iron(III) chloride; magnesium; In tetrahydrofuran; hexane; dichloromethane; acetone; 1.2: Meyers coupling / 3.2: Horner reaction;
DOI:10.1021/jo0202379

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 451478-56-1
2-(3,4-dimethoxy-2-(2-(2-methyl-tert-butoxycarbonylaminoethyl)phenyl)phenyl)-4,4-dimethyl-4,5-dihydro[1,3]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / tetrahydrofuran / 3 h / Heating

2.1: BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2.3: 1.33 g / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

With n-butyllithium; In tetrahydrofuran; hexane; 2.2: Horner reaction;
DOI:10.1021/jo0202379