6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

Base Information

Chemical Name:6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide
CAS No.:1380688-79-8
Molecular Formula:C₂₁H₂₀FN₇O
Molecular Weight:405.435
Hs Code.:

Synonyms:6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

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Chemical Property of 6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

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Technology Process of 6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

There total 10 articles about 6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1380689-21-3
6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid

: 75-31-0
isopropylamine

: 1380688-79-8
6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1380688-79-8
6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluoroacetic acid; sodium nitrite; sulfuric acid / water / 1 h / 18 °C / Cooling with ice

1.2: 10 °C / Cooling with ice

2.1: 144 h / 20 °C / Cooling with ice; Darkness

3.1: potassium hydroxide / methanol / 6 h / Reflux

4.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 1 h / -75 - -35 °C

4.2: 1 h / -78 °C

4.3: 2 h / -35 - 20 °C

5.1: bromine; acetic acid / chloroform / 2 h / Reflux

6.1: water / 3 h / 140 °C / Microwave irradiation

7.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere; Sealed flask

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; sulfuric acid; water; bromine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 3296-02-4
p-azidofluorobenzene

: 1380688-79-8
6-(4-(1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)-N-isopropylnicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 144 h / 20 °C / Cooling with ice; Darkness

2.1: potassium hydroxide / methanol / 6 h / Reflux

3.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 1 h / -75 - -35 °C

3.2: 1 h / -78 °C

3.3: 2 h / -35 - 20 °C

4.1: bromine; acetic acid / chloroform / 2 h / Reflux

5.1: water / 3 h / 140 °C / Microwave irradiation

6.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere; Sealed flask

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; water; bromine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; chloroform; water; N,N-dimethyl-formamide;