Technology Process of methyl (1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
There total 5 articles about methyl (1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen; acetic acid;
In
ethanol; ethyl acetate;
at 20 ℃;
for 2h;
DOI:10.1002/chem.201304576
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; MANDELIC ACID / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve
1.2: 1 h / -10 °C / Inert atmosphere; Molecular sieve
2.1: potassium tert-butylate / 1,2-dichloro-ethane / 1 h / -10 °C / Inert atmosphere; Molecular sieve
3.1: palladium 10% on activated carbon; acetic acid; hydrogen / ethyl acetate; ethanol / 2 h / 20 °C
With
(R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; MANDELIC ACID;
In
ethanol; ethyl acetate; 1,2-dichloro-ethane;
1.1: |Mannich Aminomethylation / 1.2: |Mannich Aminomethylation / 2.1: |Michael Addition;
DOI:10.1002/chem.201304576
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; MANDELIC ACID / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve
1.2: 1 h / -10 °C / Inert atmosphere; Molecular sieve
2.1: potassium tert-butylate / 1,2-dichloro-ethane / 1 h / -10 °C / Inert atmosphere; Molecular sieve
3.1: palladium 10% on activated carbon; acetic acid; hydrogen / ethyl acetate; ethanol / 2 h / 20 °C
With
(R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; MANDELIC ACID;
In
ethanol; ethyl acetate; 1,2-dichloro-ethane;
1.1: |Mannich Aminomethylation / 1.2: |Mannich Aminomethylation / 2.1: |Michael Addition;
DOI:10.1002/chem.201304576
