2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Base Information

Chemical Name:2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate
CAS No.:1601356-91-5
Molecular Formula:C₃₆H₃₆N₂O₇
Molecular Weight:608.691
Hs Code.:

Synonyms:2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

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Chemical Property of 2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

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Technology Process of 2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

There total 4 articles about 2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₆N₂O₇

: 1601356-91-5
2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

: 2-benzyl 3-methyl-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Guidance literature:: With potassium tert-butylate; In 1,2-dichloro-ethane; at -10 ℃; for 1h; stereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/chem.201304576

Reference yield:

: 132316-45-1,52753-91-0
methyl 2-formylcinnamate

: 1601356-91-5
2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

: 2-benzyl 3-methyl-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; MANDELIC ACID / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: 1 h / -10 °C / Inert atmosphere; Molecular sieve

2.1: potassium tert-butylate / 1,2-dichloro-ethane / 1 h / -10 °C / Inert atmosphere; Molecular sieve

With (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; potassium tert-butylate; MANDELIC ACID; In 1,2-dichloro-ethane; 1.1: |Mannich Aminomethylation / 1.2: |Mannich Aminomethylation / 2.1: |Michael Addition;
DOI:10.1002/chem.201304576

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 1601356-91-5
2-benzyl 3-methyl(1R,3S,4R)-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

: 2-benzyl 3-methyl-1-(2-methoxy-2-oxoethyl)-3-(3-methoxyphenyl)-4-(m-tolylamino)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; MANDELIC ACID / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: 1 h / -10 °C / Inert atmosphere; Molecular sieve

2.1: potassium tert-butylate / 1,2-dichloro-ethane / 1 h / -10 °C / Inert atmosphere; Molecular sieve

With (R)-3,3'-bis(4-trifluoromethylphenyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid; potassium tert-butylate; MANDELIC ACID; In 1,2-dichloro-ethane; 1.1: |Mannich Aminomethylation / 1.2: |Mannich Aminomethylation / 2.1: |Michael Addition;
DOI:10.1002/chem.201304576