4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Base Information

Chemical Name:4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline
CAS No.:1313873-24-3
Molecular Formula:C₂₅H₃₆N₂O₅
Molecular Weight:444.571
Hs Code.:

Synonyms:4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

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Chemical Property of 4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

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Technology Process of 4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

There total 6 articles about 4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1313873-31-2
6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

: 1313873-24-3
4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h; under 3750.38 Torr;
DOI:10.1016/j.bmcl.2011.04.094

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 1313873-24-3
4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 30003 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2020.112133

Reference yield:

: tert-butyl 7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)- carboxylate

: 1313873-24-3
4-(2-(6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / tetrahydrofuran / 6 h / Reflux; Inert atmosphere

2: hydrogenchloride; water / diethyl ether; dichloromethane / 20 °C

3: potassium carbonate / acetonitrile / 18 h / Reflux

4: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C / 3750.38 Torr

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.094