6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1313873-31-2
Molecular Formula:C₂₅H₃₄N₂O₇
Molecular Weight:474.554
Hs Code.:

Synonyms:6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 1313873-29-8
C₁₇H₂₇NO₅*ClH

: 1313873-31-2
6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In acetonitrile; for 18h; Reflux;
DOI:10.1016/j.bmcl.2011.04.094

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 1313996-35-8
6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4-tetrahydroisoquinoline

: 1313873-31-2
6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;
DOI:10.1016/j.ejmech.2020.112133

Reference yield:

: tert-butyl 7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)- carboxylate

: 1313873-31-2
6-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-(4-nitrophenethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / tetrahydrofuran / 6 h / Reflux; Inert atmosphere

2: hydrogenchloride; water / diethyl ether; dichloromethane / 20 °C

3: potassium carbonate / acetonitrile / 18 h / Reflux

With hydrogenchloride; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.094