2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-

Base Information

Chemical Name:2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-
CAS No.:635299-82-0
Molecular Formula:C₁₈H₃₁NO₂Si
Molecular Weight:321.535
Hs Code.:
Mol file:635299-82-0.mol

Synonyms:(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine

Suppliers and Price of 2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-
500mg
$ 696.00

ChemScene
2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-
1g
$ 1150.00

ChemScene
2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-
100mg
$ 199.00

AK Scientific
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine
5g
$ 2577.20

AK Scientific
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine
1g
$ 851.60

AK Scientific
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine
100mg
$ 330.80

Total 4 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-

Chemical Property:

Boiling Point:375.3±32.0 °C(Predicted)
PKA:14.77±0.10(Predicted)
Density:1.02±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)-

There total 8 articles about 2-Pyrrolidinemethanol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(phenylmethyl)-,(2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1318129-60-0
(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

: 635299-82-0
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1002/ejoc.201402720

Reference yield:

: 1318129-56-4
(2S,4S)-methyl 1-benzyl-4-(phenylcarbonyloxy)pyrrolidine-2-carboxylate

: 635299-82-0
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; potassium hydroxide / 0.5 h / 20 °C

2.1: thionyl chloride / 16 h / Reflux

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 1 h / 0 °C

4.2: 1 h / 0 - 20 °C

With methanol; dmap; thionyl chloride; diisobutylaluminium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201769b

Reference yield:

: 101979-12-8
2(S)-4-cis-N-benzyl-4-hydroxyproline

: 635299-82-0
(3S,5S)-1-benzyl-3-(tert-butyldimethylsilyloxy)-5-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 16 h / Reflux

2.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; dichloromethane / 1 h / 0 °C

3.2: 1 h / 0 - 20 °C

With dmap; thionyl chloride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201769b