(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate
CAS No.:1318129-60-0
Molecular Formula:C₁₉H₃₁NO₃Si
Molecular Weight:349.546
Hs Code.:

Synonyms:(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Suppliers and Price of (2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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AK Scientific
(2S,4S)-methyl1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate
1g
$ 527.60

Total 2 raw suppliers

Chemical Property of (2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2S,4S)-methyl1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate ^*data from reagent suppliers

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Technology Process of (2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

There total 4 articles about (2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318129-92-8
1-benzyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1318129-60-0
(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol201769b

Reference yield:

: 1318129-56-4
(2S,4S)-methyl 1-benzyl-4-(phenylcarbonyloxy)pyrrolidine-2-carboxylate

: 1318129-60-0
(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; potassium hydroxide / 0.5 h / 20 °C

2: thionyl chloride / 16 h / Reflux

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With methanol; dmap; thionyl chloride; triethylamine; potassium hydroxide; In dichloromethane;
DOI:10.1021/ol201769b

Reference yield:

: 101979-12-8
2(S)-4-cis-N-benzyl-4-hydroxyproline

: 1318129-60-0
(2S,4S)-methyl 1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / Reflux

2: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/ol201769b