2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

Base Information

Chemical Name:2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide
CAS No.:915006-35-8
Molecular Formula:C₂₀H₃₂N₂O₂S
Molecular Weight:364.552
Hs Code.:

Synonyms:2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

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Chemical Property of 2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

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Technology Process of 2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

There total 4 articles about 2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 859217-67-7
2-(4,4-dimethylcyclohex-1-ene-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 915006-37-0
2-(4-amino-3-bromo-phenyl)-ethanesulfonic acid tert-butylamide

: 915006-35-8
2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 19h;

Reference yield:

: 915006-39-2
2-(4-amino-phenyl)-ethanesulfonic acid tert-butylamide

: 915006-35-8
2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 5 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.09.061

Reference yield:

: 80259-15-0
2-(4-nitro-phenyl)ethanesulfonyl chloride

: 915006-35-8
2-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-ethanesulfonic acid tert-butyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h

3: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 5 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.09.061