2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

Base Information

Chemical Name:2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide
CAS No.:915006-38-1
Molecular Formula:C₁₂H₁₈N₂O₄S
Molecular Weight:286.352
Hs Code.:

Synonyms:2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

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Chemical Property of 2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

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Technology Process of 2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

There total 1 articles about 2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 80259-15-0
2-(4-nitro-phenyl)ethanesulfonyl chloride

: 75-64-9
tert-butylamine

: 915006-38-1
2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield: 95.0%

: 915006-38-1
2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

: 915006-39-2
2-(4-amino-phenyl)-ethanesulfonic acid tert-butylamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 12h;

Reference yield:

: 915006-38-1
2-(4-nitro-phenyl)-ethanesulfonic acid tert-butylamide

: 915006-36-9
4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [4-(2-(tert-butylsulfamoyl)-ethyl)-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h

2: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 5 h / 80 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.09.061