(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

Base Information

Chemical Name:(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol
CAS No.:287929-75-3
Molecular Formula:C₂₅H₂₉NO₂
Molecular Weight:375.511
Hs Code.:

Synonyms:(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

Chemical Property:

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Technology Process of (2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

There total 4 articles about (2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 91-00-9
Benzhydrylamine

: 287929-74-2
(2S,3S)-(+)-(2,4,6-timethylphenyl)oxirane-2-methanol

: 287929-75-3
(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

Guidance literature:: With lithium perchlorate; In acetonitrile; at 65 ℃; for 24h;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9

Reference yield:

: 487-68-3
mesytaldehyde

: 287929-75-3
(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / CH₂Cl₂ / 24 h / Heating

2: 86 percent / DIBAL-H / diethyl ether; hexane / 5 h / 20 °C

3: 4 Angstroem mol. sieves; titanium tetraisopropoxide; tert-butyl hydroperoxide / (+)-diisopropyl L-tartrate / CH₂Cl₂; 2,2,4-trimethyl-pentane / 8 h / -30 °C

4: 97 percent / LiClO₄ / acetonitrile / 24 h / 65 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; lithium perchlorate; diisobutylaluminium hydride; L-(+)-diisopropyl tartrate; In 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; acetonitrile; 1: Condensation / 2: Reduction / 3: Oxidation / 4: Ring cleavage;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9

Reference yield:

: 84001-90-1
(E)-ethyl 3-mesitylacrylate

: 287929-75-3
(2R,3R)-3-[(diphenylmethyl)amino]-3-(2,4,6-trimethylphenyl)propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / DIBAL-H / diethyl ether; hexane / 5 h / 20 °C

2: 4 Angstroem mol. sieves; titanium tetraisopropoxide; tert-butyl hydroperoxide / (+)-diisopropyl L-tartrate / CH₂Cl₂; 2,2,4-trimethyl-pentane / 8 h / -30 °C

3: 97 percent / LiClO₄ / acetonitrile / 24 h / 65 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; lithium perchlorate; diisobutylaluminium hydride; L-(+)-diisopropyl tartrate; In 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; acetonitrile; 1: Reduction / 2: Oxidation / 3: Ring cleavage;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9