(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Base Information

Chemical Name:(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol
CAS No.:287929-77-5
Molecular Formula:C₂₃H₄₁NO₄Si
Molecular Weight:423.668
Hs Code.:

Synonyms:(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Suppliers and Price of (1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

There total 8 articles about (1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 287929-76-4
(2R,3R)-3-{[(tert-butoxy)carbonyl]amino}-3-(2,4,6-trimethylphenyl)propane-1,2-diol

: 287929-77-5
(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9

Reference yield:

: 487-68-3
mesytaldehyde

: 287929-77-5
(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / CH₂Cl₂ / 24 h / Heating

2: 86 percent / DIBAL-H / diethyl ether; hexane / 5 h / 20 °C

3: 4 Angstroem mol. sieves; titanium tetraisopropoxide; tert-butyl hydroperoxide / (+)-diisopropyl L-tartrate / CH₂Cl₂; 2,2,4-trimethyl-pentane / 8 h / -30 °C

4: 97 percent / LiClO₄ / acetonitrile / 24 h / 65 °C

5: 68 percent / H₂ / 15 percent Pd(OH)2/C / methanol / 48 h / 20 °C / 760 Torr

6: 91 percent / 1H-imidazole / dimethylformamide / 24 h / 20 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; hydrogen; lithium perchlorate; diisobutylaluminium hydride; palladium dihydroxide; L-(+)-diisopropyl tartrate; In methanol; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Condensation / 2: Reduction / 3: Oxidation / 4: Ring cleavage / 5: Hydrogenation / 6: Etherification;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 287929-77-5
(1R,2R)-3-{[(tert-butyl)dimethylsilyl]oxy}-1-{[(tert-butoxy)carbonyl]amino}-1-(2,4,6-trimethylphenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate / 1 Torr

2: 91 percent / 1H-imidazole / dimethylformamide / 24 h / 20 °C

With 1H-imidazole; hydrogen; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; 1: Reduction / 2: Etherification;
DOI:10.1002/(SICI)1522-2675(20000510)83:5<972::AID-HLCA972>3.0.CO;2-9