Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate
CAS No.:1187918-11-1
Molecular Formula:C₁₈H₁₂Cl₂F₂N₂O₂
Molecular Weight:397.208
Hs Code.:

Synonyms:Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

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Chemical Property of Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

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Technology Process of Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

There total 3 articles about Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1273318-46-9
lithium-1-(3-chloro-5-fluorophenyl)-4-ethoxy-3,4-dioxobut-1-en-1-olate

: 175135-74-7
(3-chloro-4-fluorophenyl)hydrazine hydrochloride

: 1187918-11-1
Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: lithium-1-(3-chloro-5-fluorophenyl)-4-ethoxy-3,4-dioxobut-1-en-1-olate; (3-chloro-4-fluorophenyl)hydrazine hydrochloride; In ethanol; at 20 ℃;

With acetic acid; for 2h; Reflux;

Reference yield:

: 175135-74-7
(3-chloro-4-fluorophenyl)hydrazine hydrochloride

: 1187918-11-1
Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: In concentrated acetic acid; ethanol; ethyl acetate;

Reference yield:

: 842140-52-7
1-(3-chloro-5-fluorophenyl)ethan-1-one

: 1187918-11-1
Ethyl 1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / diethyl ether; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: ethanol / 20 °C

2.2: 2 h / Reflux

With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol;