N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

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Chemical Name:N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid
CAS No.:160447-10-9
Molecular Formula:C₂₂H₃₉NO₅
Molecular Weight:397.555
Hs Code.:

Synonyms:N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

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Chemical Property of N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

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Technology Process of N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

There total 5 articles about N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 160447-08-5
N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-(cyclopropylmethyl)-4-(1,1-dimethylethoxy)-4-oxobutanamide

: 160447-10-9
N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 7h;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 104882-45-3
(S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

: 160447-10-9
N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

2: 70 percent / TFA / CH₂Cl₂ / 7 h / 0 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 160447-06-3
3-(3-cyclopropyl-1-oxopropyl)-4(S)-(1-methylethyl)-2-oxazolidinone

: 160447-10-9
N-<<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>amino>-3(R)-(cyclopropylmethyl)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / LDA, DMPU / tetrahydrofuran / -78 °C / 1.) 1 h, 2.) 1.5 h

2: 30 percent H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

3: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

4: 70 percent / TFA / CH₂Cl₂ / 7 h / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X