N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide
CAS No.:1455036-34-6
Molecular Formula:C₁₉H₁₇FN₄O
Molecular Weight:336.369
Hs Code.:

Synonyms:N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

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Technology Process of N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

There total 6 articles about N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 6228-73-5
Cyclopropancarbamid

: 1455035-79-6
5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoroaniline

: 1455036-34-6
N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455036-34-6
N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / ethanol / 1 h / 60 °C

6: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1391740-89-8
ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate

: 1455036-34-6
N-(3-(3-amino-4-fluorophenyl)-2-methyl[1,6]naphthyridin-7-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 20 °C

4: potassium hydroxide / ethanol / 1 h / 60 °C

5: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;