(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

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Chemical Name:(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one
CAS No.:1092536-21-4
Molecular Formula:C₅₉H₆₇N₃O₉
Molecular Weight:962.196
Hs Code.:

(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

Synonyms:(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

There total 1 articles about (R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1092536-11-2
(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

: 1092536-21-4
(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

Guidance literature:: (4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; dichloromethane; at 0 ℃; for 1h; pH=7; optical yield given as %de; aq. phosphate buffer;
DOI:10.1002/anie.200801561

Reference yield: 96.0%

: 1092536-21-4
(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

: 1092536-12-3
(2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoic acid

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;
DOI:10.1002/anie.200801561