(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

Base Information

Chemical Name:(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal
CAS No.:1092536-11-2
Molecular Formula:C₄₀H₄₈N₂O₅
Molecular Weight:636.832
Hs Code.:

Synonyms:(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

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Technology Process of (2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

There total 1 articles about (2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1092536-20-3
(2S,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butan-1-ol

: 1092536-11-2
(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

Guidance literature:: (2S,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butan-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.200801561

Reference yield: 77.0%

: 1092536-11-2
(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

: 1092536-21-4
(R)-4-benzyl-3-((2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoyl)oxazolidin-2-one

Guidance literature:: (4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; dichloromethane; at 0 ℃; for 1h; pH=7; optical yield given as %de; aq. phosphate buffer;
DOI:10.1002/anie.200801561

Reference yield:

: 1092536-11-2
(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1092536-22-5
methyl (2S,3R,4S,5R)-2-(benzyloxy)-4-(dibenzylamino)-6-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-hydroxy-5-(methoxymethoxy)hexanoate

Guidance literature:: methyl 2-(benzyloxy)acetate; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

(2R,3R)-2-(dibenzylamino)-4-((4R,5S)-5-(dibenzylamino)-2,2-dimethyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)butanal; In diethyl ether; at -78 - 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; diethyl ether; at 0 ℃; for 1h; pH=7; optical yield given as %de; aq. phosphate buffer;
DOI:10.1002/anie.200801561