N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Base Information

Chemical Name:N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide
CAS No.:1268273-72-8
Molecular Formula:C₂₇H₄₁N₅O₇S
Molecular Weight:579.718
Hs Code.:

Synonyms:N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

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Chemical Property of N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

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Technology Process of N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

There total 9 articles about N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 99153-65-8
4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazine

: 1268273-71-7
N-(3-(2-fluoro-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

: 1268273-72-8
N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: In N,N-dimethyl-formamide; at 90 ℃; for 1.25h; Inert atmosphere;

Reference yield:

: 36315-01-2,256642-28-1
4,6-dimethoxy-2-aminopyrimidine

: 1268273-72-8
N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 20 h / 125 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: trifluoroacetic acid / chloroform / 22 h / 62 °C / Inert atmosphere

6.1: pyridine; pyridine hydrogenfluoride / 0 °C / Inert atmosphere

6.2: 4.5 h / 0 - 20 °C

6.3: 5 h / 20 °C

7.1: N,N-dimethyl-formamide / 1.25 h / 90 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; sodium hydride; potassium carbonate; pyridine hydrogenfluoride; triethylamine; trifluoroacetic acid; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1268273-16-0
5-iodo-4,6-dimethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine

: 1268273-72-8
N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 20 h / 125 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / chloroform / 22 h / 62 °C / Inert atmosphere

4.1: pyridine; pyridine hydrogenfluoride / 0 °C / Inert atmosphere

4.2: 4.5 h / 0 - 20 °C

4.3: 5 h / 20 °C

5.1: N,N-dimethyl-formamide / 1.25 h / 90 °C / Inert atmosphere

With pyridine; potassium carbonate; pyridine hydrogenfluoride; triethylamine; trifluoroacetic acid; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;