3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Base Information

Chemical Name:3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid
CAS No.:1000985-05-6
Molecular Formula:C₁₇H₂₄ClNO₄
Molecular Weight:341.835
Hs Code.:

Synonyms:3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Suppliers and Price of 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Technology Process of 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

There total 9 articles about 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1000985-04-5
methyl 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)propanoate

: 1000985-05-6
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Guidance literature:: methyl 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)propanoate; With lithium hydroxide; water; In tetrahydrofuran; for 4h;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield: 18.0%

: C₁₉H₂₈ClNO₄

: 1000985-05-6
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃;
DOI:10.1016/j.ejmech.2020.112076

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 1000985-05-6
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 20 °C

2.1: sodium methylate / dimethyl sulfoxide / 2 h / 20 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: tetrahydrofuran / 0 - 20 °C

5.1: tetrahydrofuran

6.1: lithium hydroxide; water / tetrahydrofuran / 4 h

6.2: pH 2 - 3

With lithium hydroxide; sulfuric acid; water; sodium methylate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;