2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide

Base Information

• Chemical Name: 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide
• CAS No.: 174180-28-0
• Molecular Formula: C₂₆H₂₅N₃O₃
• Molecular Weight: 427.503
• Mol file: 174180-28-0.mol

Synonyms:2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide

Chemical Property of 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide

There total 4 articles about 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide (161455-90-9) + malonoyl dichloride (1663-67-8) → 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide (174180-28-0)

Guidance literature:

In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1021/jm970265x

Reference yield:

2-bromo-N-isopropyl-N-phenyl-acetamide (161455-97-6) → 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide (174180-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / K₂CO₃ / dimethylformamide / 16 h / 60 °C

2: 56 percent / tetrahydrofuran / 20 h / Ambient temperature

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm970265x

Reference yield:

N-phenyl-1,2-benzenediamine (534-85-0) → 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide (174180-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 18 h

2: 36 percent / tetrahydrofuran / 5.5 h / Ambient temperature

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm960205b

upstream raw materials:

N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide

malonoyl dichloride

N-Isopropylaniline

2-bromo-N-isopropyl-N-phenyl-acetamide

Downstream raw materials:

2-[3-(N-tert-butoxycarbonyl-indol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl acetamide

2-[3-(N-tert-butoxycarbonyl-indol-2-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl acetamide

2-[2,4-Dioxo-5-phenyl-3-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl acetamide

2-(3-Allyl-3-methyl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl acetamide