ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate

Base Information

• Chemical Name: ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate
• CAS No.: 1454657-38-5
• Molecular Formula: C₁₆H₁₈N₄O₂
• Molecular Weight: 298.345
• Mol file: 1454657-38-5.mol

Synonyms:ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate

Chemical Property of ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate

There total 5 articles about ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethanol (64-17-5) + guanidinium carbonate (90332-86-8,3425-08-9) + methyl-4-(3-dimethylaminomethylene-4-oxopiperidin-1-yl)-benzoate (1454657-37-4) → ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate (1454657-38-5)

Guidance literature:

With sodium acetate trihydrate; In ethanol; for 16h; Reflux;

Reference yield:

methyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate (1454657-36-3) → ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate (1454657-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / water; tetrahydrofuran / 72 h / 20 °C

2: 1,4-dioxane / 40 h / Reflux

3: sodium acetate trihydrate / ethanol / 16 h / Reflux

With sulfuric acid; sodium acetate trihydrate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

methyl-4-(4-oxopiperidin-1-yl)-benzoate (936447-61-9) → ethyl-4-(2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-benzoate (1454657-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 40 h / Reflux

2: sodium acetate trihydrate / ethanol / 16 h / Reflux

With sodium acetate trihydrate; In 1,4-dioxane; ethanol;

upstream raw materials:

4,4-ethylenedioxy-piperidine

4-methoxycarbonylphenyl bromide

methyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate

methyl-4-(4-oxopiperidin-1-yl)-benzoate

Downstream raw materials:

4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzoic acid

4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-phenylbenzamide

4-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-(3-methylphenyl)benzamide