7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

Base Information

Chemical Name:7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride
CAS No.:946062-03-9
Molecular Formula:C₄₀H₄₁N₃O₆Si*ClH
Molecular Weight:724.328
Hs Code.:

Synonyms:7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

Chemical Property:

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Technology Process of 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

There total 6 articles about 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 946062-02-8
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine

: 946062-03-9
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 946062-01-7
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin

: 31972-52-8
Boc-Gly-Gly-OH

: 20-O-glycinate-SN-38 HCl

: 946062-03-9
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

: C₄₂H₄₄N₄O₇Si*ClH

Guidance literature:: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin; Boc-Gly-Gly-OH; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h; Overall yield = 90 %;

Reference yield:

: 946062-01-7
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin

: 946062-03-9
7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 1.75 h / 0 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In 1,4-dioxane; dichloromethane;